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RGT-018 is a potent and orally active SOS1 inhibitor with anti-tumor effects. RGT-018 exerts anti-cancer cell proliferation activity by inhibiting KRAS activation[1]. | [References]
[1] Fei Xiao, et al. "Discovery of RGT-018: A Potent, Selective, and Orally Bioavailable SOS1 Inhibitor for KRAS-Driven Cancers." Molecular Cancer Therapeutics (2024): OF1-OF14. DOI:10.1158/1535-7163.MCT-24-0049 |
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