| Identification | Back Directory | [Name]
2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindoline-5-sulfonyl fluoride | [CAS]
2803819-61-4 | [Synonyms]
EM12-SO2F
2-(2,6-dioxopiperidin-3-yl)-3-oxoisoindoline-5-sulfonyl fluoride
1H-Isoindole-5-sulfonyl fluoride, 2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-3-oxo- | [Molecular Formula]
C13H11FN2O5S | [MOL File]
2803819-61-4.mol | [Molecular Weight]
326.3 |
| Hazard Information | Back Directory | [Uses]
EM12-SO2F is a powerful covalent inhibitor of CRBN through binding at His353. EM12-SO2F is a useful chemical probe to investigate the CRBN. EM12-SO2F inhibits the degradation of IKZF1 by lenalidomide (HY-A0003) in MOLT4 cells[1][2] | [References]
[1] Lang Zheng, et al. Development of covalent inhibitors: Principle, design, and application in cancer. Volume2, Issue 4.December 2023.
[2] Cruite JT, et al. Cereblon covalent modulation through structure-based design of histidine targeting chemical probes. RSC Chem Biol. 2022 Jul 8;3(9):1105-1110. DOI:10.1039/d2cb00078d |
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