| Identification | Back Directory | [Name]
Flutonidine | [CAS]
28125-87-3 | [Synonyms]
ST-600
Flutonidine
2-(5-Fluoro-o-toluidino)-2-imidazoline
N-(5-fluoro-2-Methylphenyl)-2-iMidazolidineiMine
N-(5-Fluoro-2-methylphenyl)-4,5-dihydro-1H-imidazol-2-amine | [Molecular Formula]
C10H12FN3 | [MDL Number]
MFCD00865922 | [MOL File]
28125-87-3.mol | [Molecular Weight]
193.22 |
| Hazard Information | Back Directory | [Uses]
Flutonidine (ST-600) is a Clonidine (HY-12721) analogue that shows antihypertensive and sympatholytic effects. The initial hypertension produced by Flutonidine is due to stimulation of the peripheral α1, α2 adrenoceptors and the subsequent fall in blood pressure is due to the stimulation of central α2 adrenoceptors. Flutonidine reduces the arrhythmogenic and lethal effects of ouabain. Flutonidine is promising for research of ventricular arrhythmias caused by cardiac glycosides[1][2]. | [References]
[1] Thomas GP, et al. Effect of flutonidine on ouabain-induced arrhythmias and lethality in guinea-pig. Pharmacol Res. 1993 May-Jun;27(4):365-71. DOI:10.1006/phrs.1993.1036 |
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Leancare Ltd.
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+33 962096793 |
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www.leancare.co.uk |
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