| Identification | Back Directory | [Name]
Etoxadrol | [CAS]
28189-85-7 | [Synonyms]
Nsc288020
Etoxadrol
Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)-
Piperidine, 2-(2-ethyl-2-phenyl-1,3-dioxolan-4-yl)-, (+)-
(S)-2-[(2S)-2-Ethyl-2α-phenyl-1,3-dioxolan-4β-yl]piperidine
Piperidine, 2-[(2S,4S)-2-ethyl-2-phenyl-1,3-dioxolan-4-yl]-, (2S)- | [Molecular Formula]
C16H23NO2 | [MDL Number]
MFCD00864446 | [MOL File]
28189-85-7.mol | [Molecular Weight]
261.36 |
| Chemical Properties | Back Directory | [Boiling point ]
404.61°C (rough estimate) | [density ]
1.0086 (rough estimate) | [refractive index ]
1.5500 (estimate) | [pka]
9.57±0.10(Predicted) | [Water Solubility ]
0.65g/L(20 ºC) |
| Hazard Information | Back Directory | [Uses]
Etoxadrol (CL-1848C) is a potent, high-affinity N-methyl-D-aspartic acid (NMDA) antagonist. Etoxadrol is used in the anaesthetic and anaesthesia research community to suppress or relieve pain[1]. | [in vivo]
Etoxadrol (CL-1848C) (100.0 mg/kg; i.h.; once) produces marked stimulation and ataxia in mice[2].
Etoxadrol (0-20 mg/kg; i.v.; once) decreases brain monoamine concentrations after 4 h injection[3]. | Animal Model: | Carworth-Farm (Upjohn) male mice weighing 18 to 20 gm[2] | | Dosage: | 100.0 mg/kg | | Administration: | Subcutaneous injection, 30 min | | Result: | Produced marked stimulation and ataxia. |
| Animal Model: | Male CFE rats weighing 110-175 g (average 130 g)[3] | | Dosage: | 5, 10, and 20 mg/kg | | Administration: | Intravenous injection, once | | Result: | Significantly lowered brain serotonin, DA (dopamine), and NE (norepinephrine) concentrations at 4 h. |
| [References]
[1] A Thurkauf, et al. Synthesis, absolute configuration, and molecular modeling study of etoxadrol, a potent phencyclidine-like agonist. J Med Chem. 1988 Dec;31(12):2257-63. DOI:10.1021/jm00120a004
[2] A H Tang, et al. Analgetic activities of etoxadrol in the rhesus monkey and in mice. Anesth Analg. 1973 Jul-Aug;52(4):577-83. PMID:4197876
[3] Y F Sung, et al. Effects of intravenous anesthetics on brain monoamines in the rat. Anesthesiology. 1973 Nov;39(5):478-87. DOI:10.1097/00000542-197311000-00004 |
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