| Identification | Back Directory | [Name]
4(1H)-Quinazolinone, 5-chloro-2-(2-chloro-6-fluorophenyl)-2,3-dihydro- | [CAS]
2819989-57-4 | [Synonyms]
PBRM1BD2IN2
PBRM1-BD2-IN-2
PBRM1-BD2-IN-2, 10 mM in DMSO
4(1H)-Quinazolinone, 5-chloro-2-(2-chloro-6-fluorophenyl)-2,3-dihydro- | [Molecular Formula]
C14H9Cl2FN2O | [MOL File]
2819989-57-4.mol | [Molecular Weight]
311.14 |
| Chemical Properties | Back Directory | [Boiling point ]
512.9±50.0 °C(Predicted) | [density ]
1.433±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
11.57±0.40(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
PBRM1-BD2-IN-2 is a selective and cell-active polybromo-1 (PBRM1) bromodomain inhibitor. PBRM1-BD2-IN-2 has binding affinity and inhibitory activity for PBRM1-BD2 with Kd and IC50 values of 9.3 μM and 1.0 μM, respectively. PBRM1-BD2-IN-2 can be used for the research of cancer[1]. | [References]
[1] Shifali Shishodia, et al. Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening. J Med Chem. 2022 Oct 13. DOI:10.1021/acs.jmedchem.2c00864 |
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