2821085-76-9

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2821085-76-9 Structure

Chemical Properties	Back Directory
[Boiling point ] 555.9±50.0 °C(predicted)
[density ] 1.127±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 8.26±0.50(predicted)

Hazard Information	Back Directory
[Uses] CB2R/5-HT1AR agonist 1 (Compound 2o) is an orally active partial agonist of the CB2 receptor (EC50=479.6 nM). CB2R/5-HT1AR agonist 1 is a full agonist of 5-HT1A receptor (EC50=2.7 μM). CB2R/5-HT1AR agonist 1 exhibits anti-anxiety and anti-depressive effects. CB2R/5-HT1AR agonist 1 possesses favorable pharmacokinetic properties[1].
[References] [1] Yang W, et al. Discovery of a CB2 and 5-HT1A receptor dual agonist for the treatment of depression and anxiety. Eur J Med Chem. 2023 Dec 14;265:116048. DOI:10.1016/j.ejmech.2023.116048

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