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2821938-05-8

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2821938-05-8 Structure

2821938-05-8 Structure

Identification	Back Directory
[Name] SJF620 hydrochloride
[CAS] 2821938-05-8
[Synonyms] SJF620 hydrochloride
[Molecular Formula] C41H44N8O7.ClH
[MOL File] 2821938-05-8.mol
[Molecular Weight] 797.3

Chemical Properties	Back Directory
[form ] Solid
[color ] White to off-white

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[Uses] SJF620 hydrochloride is a PROTAC connected by ligands for Cereblon and Btk with a DC50 of 7.9 nM. SJF620 contains a Lenalidomide analog for recruiting CRBN[1].
[in vivo] SJF620 hydrochloride has a super pharmacokinetic profile in mice (1 mg/kg; i.v.) with the half life (t_1/2) of 1.64 h. SJF620 exhibits a significantly better pharmacokinetic profile than MT802^[1].
[IC 50] Cereblon
[References] [1] Jaime-Figueroa S, et al. Design, synthesis and biological evaluation of Proteolysis Targeting Chimeras (PROTACs) as a BTK degraders with improved pharmacokinetic properties. 2020 Feb 1;30(3):126877. DOI:10.1016/j.bmcl.2019.126877

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