| Identification | Back Directory | [Name]
TYRPHOSTIN A1 | [CAS]
2826-26-8 | [Synonyms]
AG 9
TYRPHOSTINA
TYRPHOSTIN 1
TYRPHOSTIN A1
TYRPHOSTIN AG 9
AKOS USSH-4110227
TYRPHOSTIN A1 99+%
RARECHEM AL BX 0083
4-METHOXYBENZLIDENEMALONONITRILE
(4-METHOXYBENZYLIDENE)MALONITRILE
(4-METHOXYBENZYLIDENE)MALONONITRILE
ALPHA-CYANO-(4-METHOXY)CINNAMONITRILE
(4-Methoxybenzylidene)malonitrile,98%
2-(4-METHOXYBENZYLIDENE)-MALONONITRILE
2-(4-Methoxybenzylidene)-malonodinitrile
2-[(4-METHOXYPHENYL)METHYLENE]MALONONITRILE
[(4-Methoxyphenyl)methylene]propanedinitrile
2-(4-Methoxyphenyl)ethene-1,1-dicarbonitrile
(4-Methoxybenzylidene)malonitrileTyrphostin 1
2-[(4-Methoxyphenyl)methylene]propanedinitrile
1-(4-METHOXYPHENYL)METHYLENE-1-PROPANEDINITRILE
1-(4-Methoxyphenyl) Methylene-1-Propanedintrile
2-[(4-methoxyphenyl)methylidene]propanedinitrile
((4-METHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE | [Molecular Formula]
C11H8N2O | [MDL Number]
MFCD00019787 | [MOL File]
2826-26-8.mol | [Molecular Weight]
184.19 |
| Chemical Properties | Back Directory | [Appearance]
light yellow crystalline needles or crystals | [Melting point ]
113-116 °C(lit.)
| [Boiling point ]
352.4±27.0 °C(Predicted) | [density ]
1.169±0.06 g/cm3(Predicted) | [storage temp. ]
2-8°C
| [solubility ]
chloroform: soluble50mg/mL, clear, light yellow | [form ]
Yellow solid | [color ]
Light orange to Yellow to Green | [Sensitive ]
Light Sensitive | [λmax]
350nm(H2O)(lit.) | [InChI]
1S/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3 | [InChIKey]
UOHFCPXBKJPCAD-UHFFFAOYSA-N | [SMILES]
COc1ccc(cc1)\C=C(/C#N)C#N |
| Hazard Information | Back Directory | [Chemical Properties]
light yellow crystalline needles or crystals | [Uses]
Tyrphostin A1 is an inactive Tyrphostin used as a negative control for Tyrphostin A23. | [Definition]
ChEBI: Tyrphostin 1 is a member of methoxybenzenes. It has a role as a geroprotector. | [Synthesis Reference(s)]
Synthetic Communications, 21, p. 1163, 1991 DOI: 10.1080/00397919108021035
Synthesis, p. 23, 1970 | [Biological Activity]
Tyrphostin 1 is a small molecule inhibitor of epidermal growth factor (EGF) receptor kinase function. This molecule associates with the substrate subsite of the protein tyrosine kinase (PTK) domain. Tyrphostin 1 is also known to block EGF-dependent receptor autophosphorylation,. Furthermorestudies have reported th at tyrphostin 1 can block Ca2+ channels and inhibit growth in vascular smooth muscle cells,.''EGFR tyrosine kinase inhibitor. |
| Safety Data | Back Directory | [Hazard Codes ]
Xn | [Risk Statements ]
20/21/22 | [Safety Statements ]
36/37 | [RIDADR ]
UN 3439 6.1/PG III | [WGK Germany ]
3
| [HazardClass ]
6.1 | [PackingGroup ]
III | [HS Code ]
29269095 | [Storage Class]
11 - Combustible Solids |
|
| Company Name: |
J & K SCIENTIFIC LTD.
|
| Telephone: |
18210857532 18210857532 |
| Website: |
https://www.jkchemical.com |
| Company Name: |
Spectrum Chemical Manufacturing Corp.
|
| Telephone: |
021-021-021-67601398-809-809-809 15221380277 |
| Website: |
www.spectrumchemical.com/oa_html/index.jsp?minisite=10020&respid=22372&language=us |
| Company Name: |
LETOPHARM LIMITED
|
| Telephone: |
+86-21-5821 5861 |
| Website: |
www.letopharm.com |
| Company Name: |
SPIRO PHARMA
|
| Telephone: |
|
| Website: |
www.spiropharma.com.cn |
|