| Identification | Back Directory | [Name]
(S)-1-((S)-1-((S)-2-Amino-3-methylbutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid trifluoroacetate | [CAS]
2828433-08-3 | [Synonyms]
(S)-1-((S)-1-((S)-2-Amino-3-methylbutanoyl)pyrrolidine-2-carbonyl)pyrrolidine-2-carboxylic acid trifluoroacetate | [Molecular Formula]
C17H26F3N3O6 | [MOL File]
2828433-08-3.mol | [Molecular Weight]
425.41 |
| Hazard Information | Back Directory | [Uses]
H-Val-Pro-Pro-OH (TFA), a milk-derived proline peptides derivative, is an inhibitor of Angiotensin I converting enzyme (ACE), with an IC50 of 9 μM. | [References]
[1] Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. DOI:10.3168/jds.S0022-0302(95)76689-9
[2] Chakrabarti S, et al. Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Enhance Insulin Sensitivity and Prevent Insulin Resistance in 3T3-F442A Preadipocytes. J Agric Food Chem. 2018 Oct 3;66(39):10179-10187. DOI:10.1021/acs.jafc.8b02051 |
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