| Identification | Back Directory | [Name]
Thalidomide-5-PEG4-COOH | [CAS]
2828438-28-2 | [Synonyms]
Thalidomide-5-PEG4-COOH
3-[2-[2-[2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-5-yl]oxy]ethoxy]ethoxy]ethoxy]-propanoic Acid | [Molecular Formula]
C22H26N2O10 | [MOL File]
2828438-28-2.mol | [Molecular Weight]
478.45 |
| Chemical Properties | Back Directory | [Boiling point ]
732.3±60.0 °C(predicted) | [density ]
1.401±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [form ]
Oil | [pka]
4.28±0.10(predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Uses]
Thalidomide-PEG4-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1]. | [IC 50]
Cereblon | [References]
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-986. DOI:10.7554/eLife.58504 |
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