| Identification | Back Directory | [Name]
BOC-GLY-GLY-GLY-OH | [CAS]
28320-73-2 | [Synonyms]
Boc-GGG-OH
BOC-(GLY)3-OH
Boc-Gly-Gly-Gly
BOC-GLY-GLY-GLY-OH
N-Boc-glycylglycylglycine
BOC-L-GLYCYL GLYCYL GLYCINE
REF DUPL: Boc-Gly-Gly-Gly-OH
Boc-Gly-Gly-Gly-OH≥ 97.5% (HPLC)
(Tert-Butoxy)Carbonyl Gly-Gly-Gly-OH
(tert-Butoxycarbonyl)glycylglycylglycine
Nα-t-Butoxycarbonyl-glycyl-glycyl-glycine
N-ALPHA-T-BUTOXYCARBONYL-GLYCYL-GLYCYL-GLYCINE
N-[N-[N-[(tert-Butoxyl)carbonyl]glycyl]glycyl]glycine
Glycine, N-[(1,1-dimethylethoxy)carbonyl]glycylglycyl-
N-[N-(N-Carboxyglycyl)glycyl]glycine N-tert-butyl ester
2,2-dimethyl-4,7,10-trioxo-3-oxa-5,8,11-triazatridecan-13-oic acid
2-[2-(2-{[(tert-butoxy)carbonyl]amino}acetamido)acetamido]acetic acid
2-[[2-[[2-[(2-methylpropan-2-yl)oxycarbonylamino]acetyl]amino]acetyl]amino]acetic acid | [Molecular Formula]
C11H19N3O6 | [MDL Number]
MFCD00190687 | [MOL File]
28320-73-2.mol | [Molecular Weight]
289.29 |
| Chemical Properties | Back Directory | [Melting point ]
205 °C | [Boiling point ]
641.8±50.0 °C(Predicted) | [density ]
1.263 | [storage temp. ]
Sealed in dry,2-8°C | [form ]
Solid | [pka]
3.33±0.10(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Chemical Properties]
White to off-white powder | [Uses]
Boc-Gly-Gly-Gly-OH is used in synthesis method for terlipressin. | [Synthesis]
GENERAL METHOD: Glycyl-glycyl-glycine (1 mmol) was slowly added to a solution of ethanol (1 mL) containing guanidine hydrochloride (15 mmol) and di-tert-butyl dicarbonate (2.5-3 mmol) under stirring conditions, and the reaction temperature was maintained at 35-40°C. The reaction mixture was stirred continuously until a clarified solution was formed. Subsequently, the ethanol was removed by evaporation under vacuum. The residue was washed sequentially with distilled water (2 mL) and hexane or petroleum ether (2 mL) to obtain almost pure Boc-glycine-glycine-glycine. The crude product can be recrystallized if further improvement of product purity is required. | [References]
[1] European Journal of Organic Chemistry, 2017, vol. 2017, # 41, p. 6209 - 6227
[2] Carbohydrate Research, 2006, vol. 341, # 10, p. 1657 - 1668
[3] Tetrahedron Letters, 2011, vol. 52, # 12, p. 1260 - 1264
[4] Organic and Biomolecular Chemistry, 2006, vol. 4, # 19, p. 3626 - 3638
[5] Tetrahedron Letters, 2000, vol. 41, # 18, p. 3433 - 3436 |
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