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TLR7 agonist 14 (compound 17b) is a highly potent TLR7 agonist with an EC50 of 18 nM. TLR7 agonist 14 potently induces the activation of mouse macrophages and hPBMCs at low-nanomolar concentrations[1]. | [IC 50]
TLR7: 18 nM (IC50) | [References]
[1] Emma G DeYoung, et al. Synthesis and Optimization of 1-Substituted Imidazo[4,5-?c]quinoline TLR7 Agonists. ACS Med Chem Lett. 2023 Sep 14;14(10):1358-1368. DOI:10.1021/acsmedchemlett.3c00260 |
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