ChemicalBook--->CAS DataBase List--->2834087-62-4

2834087-62-4

2834087-62-4 Structure

2834087-62-4 Structure
IdentificationBack Directory
[Name]

Tubulin polymerization-IN-47
[CAS]

2834087-62-4
[Synonyms]

Tubulin polymerization-IN-47
[Molecular Formula]

C22H21N3O3
[MOL File]

2834087-62-4.mol
[Molecular Weight]

375.42
Chemical PropertiesBack Directory
[density ]

1.216±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

2.349±0.30(predicted)
[color ]

Off-white to gray
Hazard InformationBack Directory
[Uses]

Tubulin polymerization-IN-47 (Compound 4h) is a tubulin polymerization inhibitor and mitotic inhibitor. Tubulin polymerization-IN-47 inhibits neuroblastoma cancer cell proliferation, with IC50s of 7 and 12 nM for Chp-134 and Kelly cell line[1].
[References]

[1] Joshua Thammathong, et al. Fused Imidazopyrazine-Based Tubulin Polymerization Inhibitors Inhibit Neuroblastoma Cell Function. ACS Med. Chem. Lett. 2023.
Spectrum DetailBack Directory
[Spectrum Detail]

Tubulin polymerization-IN-47(2834087-62-4)1HNMR
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