2834106-06-6

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2834106-06-6 Structure

Chemical Properties	Back Directory
[density ] 1.40±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ] Solid
[color ] Off-white to light yellow

Hazard Information	Back Directory
[Uses] LTGO-33 is a potent and selective voltage-gated sodium channel NaV1.8 inhibitor. LTGO-33 inhibits NaV1.8 in the nM potency range and exhibits over 600-fold selectivity against human NaV1.1-NaV1.7 and NaV1.9. LTGO-33 exhibits state-independent inhibition with similar potencies on channels in the closed and inactivated conformations. LTGO-33 inhibits native TTX-R NaV1.8 currents in non-human primate and human DRG neurons, where it reduces action potential firing. LTGO-33 can be used for pain disorders research[1].
[IC 50] hNa_v1.8
[References] [1] Gilchrist JM, et al. Pharmacologic Characterization of LTGO-33, a Selective Small Molecule Inhibitor of the Voltage-Gated Sodium Channel NaV1.8 with a Unique Mechanism of Action. Mol Pharmacol. 2024 Feb 15;105(3):233-249. DOI:10.1124/molpharm.123.000789

Spectrum Detail	Back Directory
[Spectrum Detail] LTGO-33(2834106-06-6)¹HNMR

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