2834739-51-2

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2834739-51-2 Structure

Identification	Back Directory
[Name] 2-[(2-Methyl-1-oxopropyl)amino]-N-[2-[[4-[(phenylamino)sulfonyl]benzoyl](phenylmethyl)amino]ethyl]-5-thiazolecarboxamide
[CAS] 2834739-51-2
[Synonyms] TH470 2-[(2-Methyl-1-oxopropyl)amino]-N-[2-[[4-[(phenylamino)sulfonyl]benzoyl](phenylmethyl)amino]ethyl]-5-thiazolecarboxamide
[Molecular Formula] C30H31N5O5S2
[MOL File] 2834739-51-2.mol
[Molecular Weight] 605.73

Chemical Properties	Back Directory
[density ] 1.361±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[form ] Solid
[pka] 8.04±0.10(Predicted)
[color ] White to off-white

Hazard Information	Back Directory
[Uses] TH470 is a highly selective LIMK1/2 (LIM kinase1/2) inhibitor (LIMK1 IC50=9.8 nM; LIMK2 IC50=13 nM), and can be used in orphan disease research[1].
[IC 50] LIMK1: 9.8 nM (IC₅₀); LIMK2: 13 nM (IC₅₀)
[References] [1] Hanke T, et al. Development and Characterization of Type I, Type II, and Type III LIM-Kinase Chemical Probes. J Med Chem. 2022 Oct 13;65(19):13264-13287. DOI:10.1021/acs.jmedchem.2c01106

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