| Identification | Back Directory | [Name]
Docosahexaenoyl Serotonin | [CAS]
283601-58-1 | [Synonyms]
Docosahexaenoyl Serotonin
Docosahexaenoyl Serotonin Exclusive
(4Z,7Z,10Z,13Z,16Z,19Z)-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]docosa-4,7,10,13,16,19-hexaenamide | [Molecular Formula]
C32H42N2O2 | [MOL File]
283601-58-1.mol | [Molecular Weight]
486.69 |
| Chemical Properties | Back Directory | [Boiling point ]
698.8±55.0 °C(Predicted) | [density ]
1.049±0.06 g/cm3(Predicted) | [storage temp. ]
Store at -20°C | [solubility ]
≤15mg/ml in DMSO;15mg/ml in dimethyl formamide | [form ]
solution in ethanol. | [pka]
10.07±0.40(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
Docosahexaenoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin (Catalog No. 70665). Arachidonoyl serotonin is a dual antagonist of fatty acid amide hydrolase (FAAH) and the transient receptor potential vanilloid 1 (TRPV1) channel, reducing both acute and chronic peripheral pain. The effects of replacing the arachidonoyl portion with docosahexaenoyl have not been studied. | [Uses]
Docosahexaenoyl serotonin (DHA-5-HT) is an endogenous n-3 fatty acid-serotonin conjugate. Docosahexaenoyl serotonin is an inhibitor of IL-17. Docosahexaenoyl serotonin has anti-inflammatory activity[1][2]. | [Definition]
ChEBI: Docosahexaenoyl Serotonin is a fatty amide. | [storage]
Store at -20°C | [References]
[1]. ortar g, cascio mg, de petrocellis l, et al. new n-arachidonoylserotonin analogues with potential "dual" mechanism of action against pain. j med chem. 2007 dec 27;50(26):6554-69.
[2]. maione s, de petrocellis l, de novellis v, et al. analgesic actions of n-arachidonoyl-serotonin, a fatty acid amide hydrolase inhibitor with antagonistic activity at vanilloid trpv1 receptors. br j pharmacol. 2007 mar;150(6):766-81. |
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