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2839637-72-6

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2839637-72-6 Structure

2839637-72-6 Structure
IdentificationBack Directory
[Name]

2,4(1H,3H)-Pyrimidinedione, 1-[5-[[(3S)-3,4-dimethyl-1-piperazinyl]methyl]-1,2-benzisoxazol-3-yl]dihydro-
[CAS]

2839637-72-6
[Synonyms]

2,4(1H,3H)-Pyrimidinedione, 1-[5-[[(3S)-3,4-dimethyl-1-piperazinyl]methyl]-1,2-benzisoxazol-3-yl]dihydro-
[Molecular Formula]

C18H23N5O3
[MOL File]

2839637-72-6.mol
[Molecular Weight]

357.41
Chemical PropertiesBack Directory
[density ]

1.284±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

11.72±0.20(predicted)
Hazard InformationBack Directory
[Uses]

WIZ degrader 3 (Compound 29) is a degrader for widely interspaced zinc finger motifs (WIZ), with an AC50 of 6.4 nM. WIZ degrader 3 induces the expression of fetal hemoglobin (HbF), with an EC50 of 45 nM. WIZ degrader 3 can be used for the research of blood disorders, such as sickle cell disease and β- thalassemia[1].
[References]

[1] BECKWITH IREJ, et al. Benzisoxazole derivatives and uses thereof. WO2022195355A1.
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