| Chemical Properties | Back Directory | [Boiling point ]
2439.8±65.0 °C(Predicted) | [density ]
1.354±0.06 g/cm3(Predicted) | [storage temp. ]
Desiccate at -20°C | [form ]
Solid | [pka]
3.29±0.10(Predicted) | [color ]
White to off-white | [Water Solubility ]
Soluble to 1 mg/ml in 20% acetonitrile / Water | [Sequence]
Ac-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys |
| Hazard Information | Back Directory | [Uses]
Ac9-25, a N-terminal peptide of Annexin I, acts as a formyl peptide receptor (FPR) agonist and activates the neutrophil NADPH oxidase through FPR[1][2]. | [References]
[1] Walther A, et al. A novel ligand of the formyl peptide receptor: annexin I regulates neutrophil extravasation by interacting with the FPR. Mol Cell. 2000;5(5):831-840. DOI:10.1016/s1097-2765(00)80323-8
[2] Karlsson J, et al. Neutrophil NADPH-oxidase activation by an annexin AI peptide is transduced by the formyl peptide receptor (FPR), whereas an inhibitory signal is generated independently of the FPR family receptors. J Leukoc Biol. 2005;78(3):762-771. DOI:10.1189/jlb.0305153 |
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