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2847881-42-7

2847881-42-7 Structure

2847881-42-7 Structure
IdentificationBack Directory
[Name]

5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine
[CAS]

2847881-42-7
[Synonyms]

TH-Z816
5,6,7,8-Tetrahydro-7-(8-methyl-1-naphthalenyl)-4-[(2R)-2-methyl-1-piperazinyl]-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]pyrido[3,4-d]pyrimidine
[Molecular Formula]

C29H38N6O
[MOL File]

2847881-42-7.mol
[Molecular Weight]

486.65
Chemical PropertiesBack Directory
[Boiling point ]

709.2±70.0 °C(Predicted)
[density ]

1.168±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka]

9.32±0.40(Predicted)
Hazard InformationBack Directory
[Uses]

TH-Z816 is a reversible inhibitor againstKRAS(G12D)mutation with an IC50 value of 14 μM, which can be used in cancer research[1].
[References]

[1] Zhongwei Mao, et al. KRAS(G12D) can be targeted by potent inhibitors via formation of salt bridge. Cell Discov. 2022 Jan 25;8(1):5. DOI:10.1038/s41421-021-00368-w
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