| Identification | Back Directory | [Name]
1H-Indol-4-amine, 2-[3-[[4-(dimethylphosphinyl)phenyl]amino]-1-propyn-1-yl]-N-(1-methyl-4-piperidinyl)-1-(2,2,2-trifluoroethyl)- | [CAS]
2849340-59-4 | [Synonyms]
1H-Indol-4-amine, 2-[3-[[4-(dimethylphosphinyl)phenyl]amino]-1-propyn-1-yl]-N-(1-methyl-4-piperidinyl)-1-(2,2,2-trifluoroethyl)- | [Molecular Formula]
C27H32F3N4OP | [MOL File]
2849340-59-4.mol | [Molecular Weight]
516.54 |
| Chemical Properties | Back Directory | [Boiling point ]
704.7±60.0 °C(Predicted) | [density ]
1.25±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
8.82±0.10(Predicted) | [color ]
Light yellow to orange |
| Hazard Information | Back Directory | [Uses]
p53 Activator 7 is a p53 mutation Y220C (MDM-2/p53) activator with an EC50 of 104 nM. p53 Activator 7 can bind to p53 mutant and restore its ability to bind DNA (WO2022213975A1; Example B-1)[1]. p53 Activator 7 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Sujing LI, et al. Compounds targeting y220c mutant of p53. WO2022213975A1. |
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