| | Identification | Back Directory |  | [Name] 
 STAT3-IN-35
 |  | [CAS] 
 2849535-96-0
 |  | [Synonyms] 
 STAT3-IN-35
 Naphtho[2′,1′:4,5]furo[2,3-c]pyridine-5,6-dione, 7,8,9,10-tetrahydro-9-[(1S)-1-(hydroxymethyl)-3-methylbutyl]-
 |  | [Molecular Formula] 
 C21H23NO4
 |  | [MOL File] 
 2849535-96-0.mol
 |  | [Molecular Weight] 
 353.41
 | 
 | Chemical Properties | Back Directory |  | [Boiling point ] 
 563.3±50.0 °C(predicted)
 |  | [density ] 
 1.265±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
 |  | [pka] 
 14.59±0.10(predicted)
 | 
 | Hazard Information | Back Directory |  | [Uses] 
 STAT3-IN-35 is a STAT3 inhibitor that binds to SH2 domain. STAT3-IN-35 inhibits the phosphorylation of STAT3 and possesses antiproliferative activities against triple-negative breast cancer (TNBC) cell lines. STAT3-IN-35 also has a toxicity and potent antitumor activity in a TNBC xenograft model[1].
 |  | [References] 
 [1] Fan C, et al. Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15291-15310. DOI:10.1021/acs.jmedchem.4c00872
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