Identification | Back Directory | [Name]
STAT3-IN-35 | [CAS]
2849535-96-0 | [Synonyms]
STAT3-IN-35 Naphtho[2′,1′:4,5]furo[2,3-c]pyridine-5,6-dione, 7,8,9,10-tetrahydro-9-[(1S)-1-(hydroxymethyl)-3-methylbutyl]- | [Molecular Formula]
C21H23NO4 | [MOL File]
2849535-96-0.mol | [Molecular Weight]
353.41 |
Chemical Properties | Back Directory | [Boiling point ]
563.3±50.0 °C(predicted) | [density ]
1.265±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
14.59±0.10(predicted) |
Hazard Information | Back Directory | [Uses]
STAT3-IN-35 is a STAT3 inhibitor that binds to SH2 domain. STAT3-IN-35 inhibits the phosphorylation of STAT3 and possesses antiproliferative activities against triple-negative breast cancer (TNBC) cell lines. STAT3-IN-35 also has a toxicity and potent antitumor activity in a TNBC xenograft model[1]. | [References]
[1] Fan C, et al. Natural Product-Inspired Discovery of Naphthoquinone-Furo-Piperidine Derivatives as Novel STAT3 Inhibitors for the Treatment of Triple-Negative Breast Cancer. J Med Chem. 2024 Sep 12;67(17):15291-15310. DOI:10.1021/acs.jmedchem.4c00872 |
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