| Identification | Back Directory | [Name]
Methanone, (4-phenyl-1-piperidinyl)[4-(1H-1,2,4-triazol-1-ylsulfonyl)phenyl]- | [CAS]
2851993-91-2 | [Synonyms]
HHS-0701
Methanone, (4-phenyl-1-piperidinyl)[4-(1H-1,2,4-triazol-1-ylsulfonyl)phenyl]- | [Molecular Formula]
C20H20N4O3S | [MOL File]
2851993-91-2.mol | [Molecular Weight]
396.47 |
| Chemical Properties | Back Directory | [Boiling point ]
641.6±65.0 °C(Predicted) | [density ]
1.37±0.1 g/cm3(Predicted) | [form ]
Solid | [pka]
-1.44±0.11(Predicted) | [color ]
Off-white to light yellow |
| Hazard Information | Back Directory | [Uses]
HHS-0701, a sulfur-triazole exchange (SuTEx) ligand, is a potent tyrosine-reactive prostaglandin reductase 2 (PTGR2) inhibitor. HHS-0701 blocks PTGR2 metabolism of the lipid substrate 15-Keto-PGE2[1]. | [References]
[1] Emmanuel K Toroitich, et al.Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. DOI:10.1002/cbic.202000879 |
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