| Identification | Back Directory | [Name]
thymidine 3',5'-diphosphate | [CAS]
2863-04-9 | [Synonyms]
thymidine 3',5'-diphosphate
Thymidine 3',5'-biphosphate
Thymidine 3',5'-disphosphate
Thymidine-3'',5''-bisphosphate
Thymidine-3',5'-diphosphate sodium salt | [Molecular Formula]
C10H16N2O11P2 | [MDL Number]
MFCD00036819 | [MOL File]
2863-04-9.mol | [Molecular Weight]
402.19 |
| Hazard Information | Back Directory | [Uses]
Thymidine 3',5'-disphosphate (Deoxythymidine 3′,5′-diphosphate; pdTp) is a selective small molecule inhibitor of staphylococcal nuclease and tudor domain containing 1 (SND1, the miRNA regulatory complex RISC subunit) and inhibits SND1 activity. Thymidine 3',5'-disphosphate exhibits anti-tumor efficacy in vivo[1]. | [in vivo]
Thymidine 3',5'-disphosphate (0.8 mg/kg or 1.6 mg/kg; i.p. or i.v.; twice a week for 4 weeks) significantly inhibits xenotransplantation of human hepatocellular carcinoma in WT B6/CBA mice[1].
Thymidine 3',5'-disphosphate (0.8, 0.16 and 0.32 mg/kg; s.c.; twice a week for 4 weeks) inhibits tumor proliferation, inflammatory reaction and the expression of tumor initiating cells (TIC) markers in adult male NSG mice. Thymidine 3',5'-disphosphate up-regulates the expression of apoptosis and selective tumor suppressor genes[1]. | [References]
[1] Nidhi Jariwala, et al. Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma. Cancer Res. 2017 Jun 15;77(12):3306-3316. DOI:10.1158/0008-5472.CAN-17-0298 |
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