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M4K2163 dihydrochloride is a potent, selective, blood-brain barrier (BBB) permeable activin receptor-like kinase-2 (ALK2) inhibitor, with an IC50 of 19 nM. M4K2163 dihydrochloride can be used in the research of diffuse intrinsic pontine glioma (DIPG)[1][2]. | [References]
[1] Smil D, et al. Leveraging an Open Science Drug Discovery Model to Develop CNS-Penetrant ALK2 Inhibitors for the Treatment of Diffuse Intrinsic Pontine Glioma. J Med Chem. 2020 Sep 10;63(17):10061-10085. DOI:10.1021/acs.jmedchem.0c01199
[2] Rooney L, et al. Recent Advances in ALK2 Inhibitors. ACS Omega. 2021 Aug 6;6(32):20729-20734. DOI:10.1021/acsomega.1c02983 |
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