| Chemical Properties | Back Directory | [Boiling point ]
1688.637±65.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.153±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [form ]
Solid | [pka]
3.310±0.10(predicted) | [color ]
White to off-white | [Sequence]
d-{Lys-Leu-Ala-Lys-Leu-Ala-Lys-Lys-Leu-Ala-Lys-Leu-Ala-Lys} |
| Hazard Information | Back Directory | [Uses]
d-KLA Peptide is a synthetic pro-apoptotic peptide. d-KLA Peptide can specifically target mitochondria and induce apoptosis by destroying the mitochondrial membrane. d-KLA Peptide activates biochemical pathways associated with apoptosis, including the activation of caspase family proteins and PARP (poly ADP ribose polymerase). d-KLA Peptide can be used to carry and deliver genes or small molecules to enhance anti-tumor effects[1][2]. | [References]
[1] Kim H Y, et al. The cell penetrating ability of the proapoptotic peptide, KLAKLAKKLAKLAK fused to the N-terminal protein transduction domain of translationally controlled tumor protein, MIIYRDLISH[J]. Biomaterials, 2011, 32(22): 5262-5268. DOI:10.1016/j.biomaterials.2011.03.074
[2] Ko Y T, et al. Cationic liposomes loaded with proapoptotic peptide D-(KLAKLAK) 2 and Bcl-2 antisense oligodeoxynucleotide G3139 for enhanced anticancer therapy[J]. Molecular Pharmaceutics, 2009, 6(3): 971-977. DOI:10.1021/mp900006h |
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YantaiBio
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13758194781 15083780366 |
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Fuan Bio
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18178976185 |
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