| Identification | Back Directory | [Name]
2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID | [CAS]
287118-97-2 | [Synonyms]
NCX 4040
NO-Aspirin
NO-ASPIRIN 2
2-(Acetyloxy)benzoic acid 4-(nitroxymethyl)phenyl ester
2-(Acetyloxy)benzoic acid 4-[(nitrooxy)methyl]phenyl ester
2-(ACETYLOXY)-4-[(NITROOXY)METHYL]PHENYL ESTER, BENZOIC ACID
Benzoic acid, 2-(acetyloxy)-, 4-[(nitrooxy)methyl]phenyl ester | [Molecular Formula]
C16H13NO7 | [MDL Number]
MFCD08062164 | [MOL File]
287118-97-2.mol | [Molecular Weight]
331.28 |
| Chemical Properties | Back Directory | [Melting point ]
83-86°C | [Boiling point ]
495.7±40.0 °C(Predicted) | [density ]
1.347±0.06 g/cm3(Predicted) | [storage temp. ]
-20°C | [solubility ]
DMSO: soluble15mg/mL (clear solution) | [form ]
powder | [color ]
white to beige |
| Hazard Information | Back Directory | [Chemical Properties]
Pale Yellow Solid | [Uses]
A novel nitric oxide-releasing aspirin, | [Biochem/physiol Actions]
NCX 4040 is a nitric oxide-donating form of aspirin. NCX 4040 inhibits cyclooxygenase activity and releases NO, which can down-regulate COX2 expression and reduce the levels of superoxide accumulation. In the human monocytic cell line THP1, the compound inhibits PGE2 production and cytokine expression, and appears to stabilize IkB by inhibiting proteasome function. NCX 4040 has been shown to induce apoptosis in several tumor cell lines. |
|
| Company Name: |
Sigma-Aldrich
|
| Tel: |
021-61415566 800-8193336 |
| Website: |
https://www.sigmaaldrich.cn |
| Company Name: |
Energy Chemical
|
| Tel: |
021-58432009 400-005-6266 |
| Website: |
http://www.energy-chemical.com |
| Company Name: |
Merck KGaA
|
| Tel: |
21-20338288 |
| Website: |
www.sigmaaldrich.cn |
|