2871774-93-3

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2871774-93-3 Structure

Identification	Back Directory
[Name] Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl-
[CAS] 2871774-93-3
[Synonyms] JMV6944 Benzenesulfonamide, N-[2-(7-aminoheptyl)-1-(phenylmethyl)-1H-benzimidazol-5-yl]-2,4,6-trimethyl-
[Molecular Formula] C30H38N4O2S
[MOL File] 2871774-93-3.mol
[Molecular Weight] 518.72

Chemical Properties	Back Directory
[Boiling point ] 718.7±70.0 °C(predicted)
[density ] 1.19±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka] 8.40±0.30(predicted)

Hazard Information	Back Directory
[Uses] JMV6944 is a PXR agonist. JMV6944 competitively inhibits hPXR ligand-binding domain (LBD) binding to PXR with an IC50 of 680nM. JMV6944 induces CYP3A4 mRNA expression in freshly isolated human primary human hepatocyte cultures. JMV6944 can be used for the synthesis of PROTAC PXR degrader JMV7048 (HY-162704)[1].
[References] [1] Bansard L, et al. A potent agonist-based PROTAC targeting Pregnane X Receptor that delays colon cancer relapse[J]. 2024.

2871774-93-3 suppliers list

Company Name:	Shanghai Beckham Medical Technology Co., Ltd
Tel:	021-13816613772 13816613772
Website:	www.chemicalbook.com/ShowSupplierProductsList16976/0_EN.htm

Company Name:	Wuhan Acumen Bio-Technology Co.,ltd
Tel:	027-027-16602739303 16602739303
Website:	https://www.chemicalbook.com/supplier/25442898/

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