2874264-13-6

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2874264-13-6 Structure

Identification	Back Directory
[Name] 1-[4,5-Dihydro-5-[4-(4-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-1-yl]ethanone
[CAS] 2874264-13-6
[Synonyms] 1-[4,5-Dihydro-5-[4-(4-methoxyphenoxy)phenyl]-3-(3,4,5-trimethoxyphenyl)-1H-pyrazol-1-yl]ethanone
[Molecular Formula] C27H28N2O6
[MOL File] 2874264-13-6.mol
[Molecular Weight] 476.52

Chemical Properties	Back Directory
[Boiling point ] 609.0±65.0 °C(Predicted)
[density ] 1.21±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)
[pka] -1.49±0.70(Predicted)

Hazard Information	Back Directory
[Uses] VEGFR-IN-3 (compound 3f) is a VEGFR inhibitor. VEGFR-IN-3 inhibits OVCAR-4 and MDA-MB-468 cancer cells growth with IC50s of 0.29 and 0.35 μM, respectively. VEGFR-IN-3 can be used for the research of cancer[1].
[References] [1] Hassan RA, et al. Design, synthesis and evaluation of anticancer activity of new pyrazoline derivatives by down-regulation of VEGF: Molecular docking and apoptosis inducing activity. Bioorg Chem. 2022 Jan;118:105487. DOI:10.1016/j.bioorg.2021.105487

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