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28772-56-7

28772-56-7 Structure

28772-56-7 Structure
IdentificationMore
[Name]

Bromadiolone
[CAS]

28772-56-7
[Synonyms]

3-[3-(4'-BROMO[1,1'BIPHENYL]-4-YL)-3-HYDROXY-1-PHENYLPROPYL]-4-HYDROXY-2H-1 BENZOPYRAN-2-ONE
3-(3-(4'-bromo-(1,1'-biphenyl)-4-yl)-3-hydroxy-1-phenylpropyl)-4-hydroxycoumarin
ACILONE
ACILONE SUPER
BROMADIOLON
BROMADIOLONE
BROPRODIFACOUM
KILLRAT
LANIRAT
MAKI
MAKI(R)
Musal
RATOBAN
SUPER CAID
SUPER-ROZOL
(hydroxy-4coumarinyl3)-3phenyl-3(bromo-4biphenylyl-4)-1propanol-1
(hydroxy-4-coumarinyl-3)-3-phenyl-3-(bromo-4-biphenylyl-4)-1-propanol-1(french
1’-biphenyl)-4-yl)3-hydroxy-1-phenylpropyl)-4-hydroxy-2h-1-3-(3-(4’-bromo(
2h-1-benzopyran-2-one,3-(3-(4`-bromo-(1,1`-biphenyl)-4-yl)-3-hydroxy-1-phenylp
2h-1-benzopyran-2-one,3-(3-(4’-bromo(1,1’-biphenyl)-4-yl)-3-hydroxy-1-phenylp
[EINECS(EC#)]

249-205-9
[Molecular Formula]

C30H23BrO4
[MDL Number]

MFCD00128053
[Molecular Weight]

527.41
[MOL File]

28772-56-7.mol
Chemical PropertiesBack Directory
[Appearance]

Bromadiolone is white to off-white (yellowish) powder.
[Melting point ]

200-210°
[Boiling point ]

723.4±60.0 °C(Predicted)
[density ]

1.3243 (rough estimate)
[vapor pressure ]

2 x l0-6Pa (20 °C)
[refractive index ]

1.4490 (estimate)
[storage temp. ]

-20°C
[solubility ]

DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml
[form ]

Powder
[pka]

4.04(at 21℃)
[Water Solubility ]

19 mg l-1 (20 °C)
[Merck ]

13,1366
[BRN ]

1335336
[LogP]

7.480 (est)
[CAS DataBase Reference]

28772-56-7(CAS DataBase Reference)
[EPA Substance Registry System]

28772-56-7(EPA Substance)
Safety DataBack Directory
[Hazard Codes ]

T+
[Risk Statements ]

R27/28:Very Toxic in contact with skin and if swallowed .
[Safety Statements ]

S28:After contact with skin, wash immediately with plenty of ... (to be specified by the manufacturer) .
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection .
S45:In case of accident or if you feel unwell, seek medical advice immediately (show label where possible) .
[RIDADR ]

UN 2811
[WGK Germany ]

3
[RTECS ]

GN4934700
[HazardClass ]

6.1(a)
[PackingGroup ]

I
[Hazardous Substances Data]

28772-56-7(Hazardous Substances Data)
[Toxicity]

LD50 in rats, mice (mg/kg): 1.125, 1.75 orally (Grand)
Raw materials And Preparation ProductsBack Directory
[Raw materials]

Government regulation-->Benzene-->Isopropyl alcohol-->Acetyl chloride-->Benzaldehyde-->Ethylene glycol-->Styrene-->Potassium borohydride-->Biphenyl-->4-Hydroxycoumarin-->Warfarin-->Coumarin-->4-Bromobiphenyl-->METHOXYPHENONE
Hazard InformationBack Directory
[General Description]

Yellowish powder. Used as an anticoagulant rodenticide.
[Health Hazard]

The compound is toxic by oral exposure.
[Potential Exposure]

Bromadiolone is used as an anticoagulant rodenticide. It is bait for rodent control used against house mice, roof rats, warfarin-resistant Norway rats. It is also authorized by USDA for use in official establishments operating under the federal meat, poultry, shell egg grading, and egg products inspection program. May be used as a drug.
[Fire Hazard]

(Non-Specific--Coumarin Derivative Pesticide, Solid, n.o.s.) Fire may produce irritating or poisonous gases. Runoff from fire control water may give off poisonous gases. Runoff from fire control or dilution water may cause pollution. When heated to decomposition, BROMADIOLONE emits toxic fumes of bromine containing compounds.
[First aid]

If this chemical gets into the eyes, remove any contact lenses at once and irrigate immediately for at least 15 minutes, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts the skin, remove contaminated clothing and wash immediately with soap and water. Seek medical attention immediately. If this chemical has been inhaled, remove from exposure, begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR if heart action has stopped. Transfer promptly to a medical facility. When this chemical has been swallowed, get medical attention. Give large quantities of water and induce vomiting. Do not make an unconscious person vomit. Keep victim quiet and maintain normal body temperature. Effects may be delayed; keep victim under observation.
[Shipping]

UN3027 Coumarin derivative pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1—Poisonous materials. UN3026 Coumarin derivative pesticides, liquid, toxic, Hazard Class: 6.1; Labels: 6.1—Poisonous materials.
[Description]

Bromadiolone is used to control rodents around buildings, inside transport vehicles and sewers. It is often formulated as meal bait, rat and mouse bait ready-to-use place packs, paraffinized pellets and blocks.
[Chemical Properties]

Bromadiolone is white to off-white (yellowish) powder.
[Occurrence]

Boldo is an evergreen found in Chile, Peru, and Morocco.
[Uses]

Bromadiolone is an anticoagulant rodenticide used on non-crop areas.
[Uses]

Bromadiolone is used for the control of rats and mice.
[Uses]

Rodenticide.
[Definition]

ChEBI: Bromadiolone is a diarylheptanoid.
[Agricultural Uses]

Rodenticide: Bromadiolone is used as an anticoagulant rodenticide and used as bait for rodent control against house mice, roof rats and warfarin-resistant Norway rats. It is also authorized by USDA for use in official establishments operating under the Federal meat, poultry, shell egg grading and egg products inspection program.
[Trade name]

BOLDO®; BOOT HILL®; BROMONE®; CANADIEN 2000®; CONTRAC®; HAWK®; LM- 637®; MAKI®; RAT ARREST®; RAT FREE®; RATIMUS®; RENTOKIL DEADLINE®; SLAYMOR®; SUPER-CAID®; SUPER-ROZOL®; SUP'ORATS®; TERMUS®
[Environmental Fate]

Bromadiolone belongs to second generation of long-acting anticoagulant rodenticide. It acts by interfering with the prothrombin synthesis by blocking the regeneration of vitamin K dependant proteins in the liver and thereby disrupting the clotting mechanisms and increasing the tendency to hemorrhages and subsequent death.
[Metabolic pathway]

Metabolism in the rat is very slow and products other than a conjugate of the parent compound have not been identified. Biodegradation in soil and plants has not been reported.
[storage]

Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with bromadiolone you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area.
[Degradation]

Bromadiolone is a stable compound. It is a weak acid.
[Toxicity evaluation]

Bromadiolone may be released into the environment through various waste streams and its use. If released to air, it will exist in the particulate phase in the ambient atmosphere and will be removed by dry and wet deposition. In soil, it is not persistent under aerobic conditions (half-life is 14 days) and is usually immobile except in soils of low organic matter and clay, such as sand.
When released to water, it adsorbs to suspended solids and sediment. Bromadiolone is stable to hydrolysis at pH 5, 7, and 9. Two major degradates, [1,3-diphenyl-5(40-bromobiphenyl) pentane-1-ol] and [1,3-diphenyl-5(40-bromobiphenyl) pentane-1,5-diol], are detected in the aerobic soil metabolism study.
Bromadiolone is bioaccumulated in edible and nonedible tissues in bluegill sunfish at the bioaccumulation concentration factors of 160X and 1658X. It was also detected in birds.
Material Safety Data Sheet(MSDS)Back Directory
[msds information]

Bromadiolone(28772-56-7).msds
Well-known Reagent Company Product InformationBack Directory
[Sigma Aldrich]

28772-56-7(sigmaaldrich)
28772-56-7 suppliers list
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