| Identification | Back Directory | [Name]
NORDIHYDROCAPSAICIN | [CAS]
28789-35-7 | [Synonyms]
Norhydrocapsaicin
Nordihydrocapsaic
NORDIHYDROCAPSAICIN
NORDIHYDROCAPSAICIN USP/EP/BP
N-(4-Hydroxy-3-methoxybenzyl)-7-methyloctanamide
N-[(4-Hydroxy-3-methoxyphenyl)methyl]-7-methyl-octanamide
Octanamide,N-[(4-hydroxy-3-methoxyphenyl)methyl]-7-methyl- | [Molecular Formula]
C17H27NO3 | [MDL Number]
MFCD06796690 | [MOL File]
28789-35-7.mol | [Molecular Weight]
293.4 |
| Chemical Properties | Back Directory | [Boiling point ]
487.0±35.0 °C(Predicted) | [density ]
1.036±0.06 g/cm3 (20 ºC 760 Torr) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Chloroform: soluble; DMSO: soluble | [form ]
A crystalline solid | [pka]
9.76±0.20(Predicted) | [color ]
Light brown to gray | [InChI]
InChI=1S/C17H27NO3/c1-13(2)7-5-4-6-8-17(20)18-12-14-9-10-15(19)16(11-14)21-3/h9-11,13,19H,4-8,12H2,1-3H3,(H,18,20) | [InChIKey]
VQEONGKQWIFHMN-UHFFFAOYSA-N | [SMILES]
C(NCC1=CC=C(O)C(OC)=C1)(=O)CCCCCC(C)C | [LogP]
3.046 (est) | [EPA Substance Registry System]
Nordihydrocapsaicin (28789-35-7) |
| Hazard Information | Back Directory | [Uses]
Nordihydrocapsaicin is a capsaicinoid and analog and congener of capsaicin in chili peppers. | [Definition]
ChEBI: Nordihydrocapsaicin is a member of methoxybenzenes and a member of phenols. | [in vivo]
Nordihydrocapsaicin (0.1-0.2% CAPs (10 mg/kg BW), p.o., daily for 8 weeks) prevents low-fat-high carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways in rats[4].
| Animal Model: | Wistar rats [4] | | Dosage: | 0.1%–0.2% CAPs (10 mg/kg BW) | | Administration: | p.o., daily for 8 weeks | | Result: | Caused a 32% and 37% reduction for HSD and 16% and 18% reduction for HFD in serum and liver MDA concentrations and elevation in serum TAC by 163% and 54% in the HSD- and HFD-fed rats (P<0.001), respectively. |
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