| Identification | Back Directory | [Name]
α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide | [CAS]
2883115-46-4 | [Synonyms]
ML162-yne
α-[(2-Chloroacetyl)[3-chloro-4-(2-propyn-1-yloxy)phenyl]amino]-N-(2-phenylethyl)-2-thiopheneacetamide | [Molecular Formula]
C25H22Cl2N2O3S | [MOL File]
2883115-46-4.mol | [Molecular Weight]
501.42 |
| Chemical Properties | Back Directory | [Boiling point ]
719.4±60.0 °C(Predicted) | [density ]
1.346±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [solubility ]
DMSO: Soluble: =10 mg/ml | [form ]
Solid | [pka]
13.83±0.46(Predicted) | [color ]
White to off-white |
| Hazard Information | Back Directory | [Uses]
ML162-yne is a potent GPX4-inhibitor affinity probe[1]. ML162-yne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. | [References]
[1] Eaton JK, et al. Selective covalent targeting of GPX4 using masked nitrile-oxide electrophiles. Nat Chem Biol. 2020 May;16(5):497-506. DOI:10.1038/s41589-020-0501-5 |
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