| Identification | Back Directory | [Name]
Tricyclo[3.3.1.13,7]decane-1-carboxamide, N-[4-[(phenylsulfonyl)oxy]phenyl]- | [CAS]
2883495-35-8 | [Synonyms]
Enpp/Carbonic anhydrase-IN-1
4-(Adamantane-1-carboxamido)phenyl benzenesulfonate
Tricyclo[3.3.1.13,7]decane-1-carboxamide, N-[4-[(phenylsulfonyl)oxy]phenyl]- | [Molecular Formula]
C23H25NO4S | [MOL File]
2883495-35-8.mol | [Molecular Weight]
411.51 |
| Chemical Properties | Back Directory | [Boiling point ]
625.8±47.0 °C(Predicted) | [density ]
1.342±0.06 g/cm3(Predicted) | [form ]
Solid | [pka]
13.70±0.70(Predicted) | [color ]
White to light yellow |
| Hazard Information | Back Directory | [Uses]
Enpp/Carbonic anhydrase-IN-1 (compound 1e) is a potent Enpp and carbonic anhydrase inhibitor with IC50s of 1.36, 1.35, 3.00, 0.88, 1.02 μM for NPP1, NPP2, NPP3, CA-II, CA-IX respectively. Enpp/Carbonic anhydrase-IN-1 shows antiproliferative activity for cancer cells and low cytotoxic against normal cells. Enpp/Carbonic anhydrase-IN-1 induces Apoptosis[1]. | [IC 50]
CA Ⅱ: 0.88 μM (IC50); CA Ⅸ: 1.02 μM (IC50); NPP1: 1.36 μM (IC50); NPP2: 1.35 μM (IC50); NPP3: 3.00 μM (IC50) | [References]
[1] Afnan I.Shahin, et al. Design and synthesis of new adamantyl derivatives as promising antiproliferative agents. European Journal of Medicinal Chemistry, 2022. |
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