| Identification | Back Directory | [Name]
FAK inhibitor 7 | [CAS]
2890814-94-3 | [Synonyms]
FAK inhibitor 7
1H-Inden-1-one, 2,3-dihydro-7-[[2-[[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl]oxy]- | [Molecular Formula]
C32H37N7O3 | [MOL File]
2890814-94-3.mol | [Molecular Weight]
567.68 |
| Hazard Information | Back Directory | [Uses]
FAK inhibitor 7 is a type of FAK inhibitor with an IC50 value of 3.58 nM. FAK inhibitor 7 can inhibit the downstream signaling cascades of FAK (like Src and AKT), causing ovarian cancer cells to stall in the G0/G1 phase and induce cytotoxic autophagy. FAK inhibitor 7 can also suppress tumor metastasis and growth in ovarian cancer mice[1]. | [References]
[1] Feng Z, et al. A novel selective FAK inhibitor E2 inhibits ovarian cancer metastasis and growth by inducing cytotoxic autophagy. Biochem Pharmacol. 2024 Aug 3;229:116461. DOI:10.1016/j.bcp.2024.116461 |
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