| Identification | Back Directory | [Name]
Methanone, (4-amino-4-methyl-1-piperidinyl)[5-[(2,3-dichlorophenyl)thio]-2-furanyl]- | [CAS]
2892720-11-3 | [Synonyms]
Methanone, (4-amino-4-methyl-1-piperidinyl)[5-[(2,3-dichlorophenyl)thio]-2-furanyl]- | [Molecular Formula]
C17H18Cl2N2O2S | [MOL File]
2892720-11-3.mol | [Molecular Weight]
385.31 |
| Hazard Information | Back Directory | [Uses]
SDUY038 is a SHP2 allosteric inhibitor, with an IC50 of 1.2 μM and KD of 0.29 μM, respectively. SDUY038 exhibits pan-antitumor activity (IC50 = 7-24 μM) by suppressing pERK expression. SDUY038 exhibits t1/2 of 3.95 h by oral administration[1]. | [References]
[1] Chengchun Zhu, et al. Design, Synthesis and Antitumor Activity of a Novel Class of SHP2 Allosteric Inhibitors with a Furanyl Amide-Based Scaffold. J Med Chem. 2024 Aug 8;67(15):13305-13323. DOI:10.1021/acs.jmedchem.4c01217 |
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