| Chemical Properties | Back Directory | [Boiling point ]
545.8±50.0 °C(predicted) | [density ]
1.250±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted) | [pka]
8.75±0.10(predicted) |
| Hazard Information | Back Directory | [Uses]
BDM91288 is an orally active AcrB efflux pump inhibitor of pyridinium piperazine. BDM91288 can enhance the in vivo efficacy of levofloxacin (HY-B0330) in the treatment of Klebsiella pneumoniae pulmonary infection in mouse models[1]. | [References]
[1] Vieira Da Cruz A, et al. Pyridylpiperazine efflux pump inhibitor boosts in vivo antibiotic efficacy against K. pneumoniae. EMBO Mol Med. 2024 Jan;16(1):93-111. DOI:10.1038/s44321-023-00007-9 |
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