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2894733-91-4

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2894733-91-4 Structure

2894733-91-4 Structure
IdentificationBack Directory
[Name]

PD-L1-IN-2
[CAS]

2894733-91-4
[Synonyms]

PD-L1-IN-2
[Molecular Formula]

C33H38N4O6
[MOL File]

2894733-91-4.mol
[Molecular Weight]

586.68
Chemical PropertiesBack Directory
[density ]

1.18±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[form ]

Solid
[pka]

12.60±0.70(predicted)
[color ]

White to off-white
Hazard InformationBack Directory
[Uses]

PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1. PD-L1-IN-2 is a Naamidine J derivative and exerts antitumor effects in vivo by reducing PD-L1 expression and enhancing tumor-infiltrating T-cell immunity. PD-L1-IN-2 is used for colorectal cancer research[1].
[in vivo]

PD-L1-IN-2 (compound 11c) (i.p.; 25/50 mg/kg; once a day; 16 days) decreases the tumor sizes with an inhibition rate of 45% at 45 mg/kg, and the average tumor weight of the 50 mg/kg groups is significantly lower than that of the PBS group[1].

Animal Model:C57BL/6 mice with subcutaneous MC38 tumors[1]
Dosage:25/50 mg/kg
Administration:i.p.; 25/50 mg/kg; once a day; 16 days
Result:Suppressed MC38 tumor growth in vivo.
[References]

[1] Pan-Pan Fu, et al. Bioactivity-Driven Synthesis of the Marine Natural Product Naamidine J and Its Derivatives as Potential Tumor Immunological Agents by Inhibiting Programmed Death-Ligand 1. J Med Chem. 2023 Apr 27;66(8):5427-5438. DOI:10.1021/acs.jmedchem.2c01702
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