| Identification | Back Directory | [Name]
2-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE | [CAS]
28948-61-0 | [Synonyms]
2-broMo-4-chlorothieno[3
2-BROMO-4-CHLOROTHIENO[3,2-C]PYRIDINE
Thieno[3,2-c]pyridine, 2-bromo-4-chloro- | [Molecular Formula]
C7H3BrClNS | [MDL Number]
MFCD08273916 | [MOL File]
28948-61-0.mol | [Molecular Weight]
248.53 |
| Chemical Properties | Back Directory | [Melting point ]
119 °C | [Boiling point ]
355.2±37.0 °C(Predicted) | [density ]
1.849±0.06 g/cm3(Predicted) | [storage temp. ]
under inert gas (nitrogen or Argon) at 2-8°C | [form ]
solid | [pka]
-1.38±0.40(Predicted) | [color ]
Yellow |
| Hazard Information | Back Directory | [Synthesis]
General procedure for the synthesis of 2-bromo-4-chlorothieno[3,2-C]pyridine from 2-bromo-4-hydroxythieno[3,2-C]pyridine: Phosphorus oxychloride (4.08 g, 26.6 mmol) was slowly added dropwise to a mixture of 2-bromothieno[3,2-c]pyridin-4(5H)-one (2.04 g, 8.87 mmol), and the reaction was carried out at 0 °C. Subsequently, the reaction mixture was heated to 135 °C for 2.5 hours. After completion of the reaction, the mixture was carefully poured onto ice water. The precipitate was collected by filtration and dried to afford 1.78 g (80.7% yield) of the target product 2-bromo-4-chlorothieno[3,2-C]pyridine. The product was characterized by 1H NMR (270 MHz, CH3OH-d4): δ 7.67 (d, 1H), 7.88 (dddd, J = 6.33 Hz, 2H), 8.19 (d, J = 5.54 Hz, 1H); the mass spectrometry (MS) showed the molecular ion peak as 248.0 (M-H)+; and the high-performance liquid chromatography (HPLC) analysis showed the purity as 100%. | [References]
[1] Patent: WO2004/828, 2003, A1 |
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