| Identification | Back Directory | [Name]
3-Quinolinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-1,4-dihydro-4-oxo-1-phenyl- | [CAS]
2896204-90-1 | [Synonyms]
3-Quinolinecarboxamide, N-[4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-1,4-dihydro-4-oxo-1-phenyl- | [Molecular Formula]
C33H25N3O5 | [MOL File]
2896204-90-1.mol | [Molecular Weight]
543.57 |
| Chemical Properties | Back Directory | [Boiling point ]
734.7±60.0 °C(Predicted) | [density ]
1.346±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted) | [pka]
11.33±0.70(Predicted) |
| Hazard Information | Back Directory | [Uses]
Anti-inflammatory agent 41 (13a) significantly inhibit lipopolysaccharide (LPS)-induced expression of the proinflammatory cytokines IL-6 and TNF-α on J774A.1, THP-1 and LX-2 cells, and inhibits the activation of the NF-κB pathway[1]. | [References]
[1] Jun Yang, et al. Discovery of 4-oxo-N-phenyl-1,4-dihydroquinoline-3-carboxamide derivatives as novel anti-inflammatory agents for the treatment of acute lung injury and sepsis. Eur J Med Chem. 2023 Mar 5;249:115144. DOI:10.1016/j.ejmech.2023.115144 |
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