| Chemical Properties | Back Directory | [Boiling point ]
726.678±60.00 °C(Press: 760.00 Torr)(predicted) | [density ]
1.478±0.10 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | [pka]
12.593±0.70(predicted) |
| Hazard Information | Back Directory | [Uses]
AR antagonist 5 (compound 30a) is a selective androgen receptor (AR) antagonist with an IC50 value of 134.8 nM. AR antagonist 5 has favorable pharmacokinetic properties and shows a high skin exposure and low plasma exposure[1. | [References]
[1] Wenqiang Zhang, et al. Discovery of (2 S)- N-(6-Cyano-5-(trifluoromethyl)pyridin-3-yl)-3-(6-(4-cyanophenyl)-3,6-diazabicyclo[3.1.1]heptan-3-yl)-2-hydroxy-2-methylpropanamide as a Highly Potent and Selective Topical Androgen Receptor Antagonist for Androgenetic Alopecia Treatment. J Med Chem. 2024, 67,1. DOI:10.1021/acs.jmedchem.3c01417 |
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