| Identification | Back Directory | [Name]
6-PHENYLNICOTINIC ACID | [CAS]
29051-44-3 | [Synonyms]
6-phnylnicotinic acid
6-PHENYLNICOTINIC ACID
6-Phenylnicotinic acid 90%
6-Phenylnicotinic acid, 90+%
6-phenylpyridine-3-carboxylicaci
6-PHENYLPYRIDINE-3-CARBOXYLIC ACID
6-Phenyl-3-pyridinecarboxylic acid
2-Phenyl-5-pyridinecarboxylic acid
6-PHENYLPYRIDIN-3-YLCARBOXYLIC ACID
3-Pyridinecarboxylic acid, 6-phenyl-
6-Phenylpyridine-3-carboxylic acid, 5-Carboxy-2-phenylpyridine
6-Phenylpyridine-3-carboxylic acid, 3-Carboxy-6-phenylpyridine
N-[(E)-(2,3-dimethoxyphenyl)methylideneamino]-5-nitro-2-pyridinamine | [EINECS(EC#)]
249-386-4 | [Molecular Formula]
C12H9NO2 | [MDL Number]
MFCD03086128 | [MOL File]
29051-44-3.mol | [Molecular Weight]
199.21 |
| Chemical Properties | Back Directory | [Melting point ]
243 °C | [Boiling point ]
388.1±30.0 °C(Predicted) | [density ]
1.241±0.06 g/cm3(Predicted) | [storage temp. ]
Inert atmosphere,Room Temperature | [form ]
powder to crystal | [pka]
2.19±0.10(Predicted) | [color ]
White to Light yellow |
| Hazard Information | Back Directory | [Synthesis Reference(s)]
Journal of the American Chemical Society, 99, p. 3166, 1977 DOI: 10.1021/ja00451a053 | [Synthesis]
Under argon protection, 6-bromonicotinic acid (1 eq.), phenylboronic acid (1.2 eq.) and tetrakis(triphenylphosphine)palladium (1 mol%) were dissolved in a solvent mixture of dioxane and water (10:1 by volume). Potassium carbonate (2 equivalents) was then added and the reaction mixture was heated to reflux for 6 hours. After completion of the reaction, it was cooled to room temperature and the dioxane was removed by rotary evaporator. Water was added and the pH of the solution was adjusted to 1-3 with 2 N hydrochloric acid. the precipitated white solid precipitate was collected by filtration and dried to give 6-phenylnicotinic acid. | [References]
[1] Inorganic Chemistry, 2012, vol. 51, # 4, p. 2105 - 2114
[2] European Journal of Inorganic Chemistry, 2012, # 7, p. 1025 - 1037
[3] Organic Letters, 2016, vol. 18, # 23, p. 6094 - 6097
[4] European Journal of Medicinal Chemistry, 2017, vol. 137, p. 96 - 107 |
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J & K SCIENTIFIC LTD.
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18210857532 18210857532 |
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https://www.jkchemical.com |
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