| Identification | Back Directory | [Name]
(9β,10α)-2β,16α-Dihydroxy-4,4,9,14-tetramethyl-19-norpregna-5-ene-3,11,20-trione | [CAS]
29065-05-2 | [Synonyms]
Hexanorcucurbitacin D
(10α)-2β,16α-Dihydroxy-4,4,9β,14-tetramethyl-19-norpregn-5-ene-3,11,20-trione
(9β,10α)-2β,16α-Dihydroxy-4,4,9,14-tetramethyl-19-norpregna-5-ene-3,11,20-trione
19-Norpregn-5-ene-3,11,20-trione, 2,16-dihydroxy-4,4,9,14-tetramethyl-, (2β,9β,10α,16α)-
(10α)-2β,16α-Dihydroxy-19,22,23,24,25,26,27-hepta-nor-9β-methyllanost-5-ene-3,11,20-trione | [Molecular Formula]
C24H34O5 | [MOL File]
29065-05-2.mol | [Molecular Weight]
402.52 |
| Hazard Information | Back Directory | [Uses]
Hexanorcucurbitacin D, a cucurbitacin, is a weak ecdysteroid receptor agonist. Hexanorcucurbitacin D can be isolated from Trichosanthes cucumeroides roots. Hexanorcucurbitacin D can be used for the research of cardiovascular disease (CVD)[1][2]. | [References]
[1] Xianjing Zhang, et al. Lipid-Lowering Activities of Cucurbitacins Isolated from Trichosanthes cucumeroides and Their Synthetic Derivatives. J Nat Prod. 2020 Dec 24;83(12):3536-3544. DOI:10.1021/acs.jnatprod.0c00364
[2] L Dinan, et al. Cucurbitacins are insect steroid hormone antagonists acting at the ecdysteroid receptor. Biochem J. 1997 Nov 1;327 ( Pt 3)(Pt 3):643-50. DOI:10.1042/bj3270643 |
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