| Identification | Back Directory | [Name]
5-Hydroxy-3',4',7-trimethoxyflavone | [CAS]
29080-58-8 | [Synonyms]
Gonzalitosin I
Rutoside Trihydrate Impurity 12
Luteolin 7,3',4'-trimethyl ether
2-(3,4-dimethoxyphenyl)-5-hydroxy-7-methoxychromen-4-one
2-(3,4-DiMethoxyphenyl)-5-hydroxy-7-Methoxy-4H-chroMen-4-one
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone)
4H-1-Benzopyran-4-one, 2-(3,4-diMethoxyphenyl)-5-hydroxy-7-Methoxy- | [Molecular Formula]
C18H16O6 | [MDL Number]
MFCD19441043 | [MOL File]
29080-58-8.mol | [Molecular Weight]
328.32 |
| Chemical Properties | Back Directory | [Melting point ]
163 °C | [Boiling point ]
536.3±50.0 °C(Predicted) | [density ]
1.314±0.06 g/cm3(Predicted) | [storage temp. ]
Sealed in dry,2-8°C | [solubility ]
Soluble in DMSO | [form ]
Solid | [pka]
6.32±0.40(Predicted) | [color ]
White to yellow |
| Hazard Information | Back Directory | [Uses]
7,3',4'-Tri-O-methylluteolin (5-Hydroxy-3',4',7-trimethoxyflavone), a flavonoid compound, possesses potent anti-inflammatory effects in LPS-induced macrophage cell line mediated by inhibition of release of inflammatory mediators, NO, PGE2, and pro-inflammatory cytokines. 7,3',4'-Tri-O-methylluteolin significantly induces reduction in the mRNA expressions of inducible nitric oxide synthase and cyclooxygenase-2[1]. | [IC 50]
IL-6; IL-1β; COX-2 | [References]
[1] Sudha, A, et al. Protective effect of 5-hydroxy-3′,4′,7-trimethoxyflavone against inflammation induced by lipopolysaccharide in RAW 264.7 macrophage: in vitro study and in silico validation. Medicinal Chemistry Research, 2016,25(9), 1754–1767. |
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