ChemicalBook--->CAS DataBase List--->2918263-09-7

2918263-09-7

2918263-09-7 Structure

2918263-09-7 Structure
IdentificationBack Directory
[Name]

LBA-3
[CAS]

2918263-09-7
[Synonyms]

LBA-3
[Molecular Formula]

C18H18O5
[MOL File]

2918263-09-7.mol
[Molecular Weight]

314.33
Chemical PropertiesBack Directory
[Boiling point ]

526.1±50.0 °C(predicted)
[density ]

1.307±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
[pka]

3.54±0.28(predicted)
Hazard InformationBack Directory
[Uses]

LBA-3 is a selective, orally active inhibitor for sodium-coupled citrate transporter SLC13A5, with an IC50 of 67 nM. LBA-3 decreases levels of triglyceride and total cholesterol in oleic and palmitic acid (OPA)-stimulated AML12 cells, PCN-stimulated primary mouse hepatocytes and in mouse models, without detectable toxicity. LBA-3 is blood-brain barrier permeable[1].
[in vivo]

LBA-3 (50 mg/kg, po, single dose) exhibits a pharmacokinetic profil in Sprague Dawley rats, with peak plasma concentration Cmax of 288?262.00 μg/L, AUC of 704?570.43 h/μg–1·L and an oral bioavailability of 48.67%[1].

[References]

[1] Zhang L, et al., Discovery of Highly Potent Solute Carrier 13 Member 5 (SLC13A5) Inhibitors for the Treatment of Hyperlipidemia. J Med Chem. 2024 Apr 25;67(8):6687-6704. DOI:10.1021/acs.jmedchem.4c00260
2918263-09-7 suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Website: https://www.targetmol.cn/
Tags:2918263-09-7 Related Product Information

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.