| Hazard Information | Back Directory | [Uses]
hBChE-IN-2 (compound 15d) is a butyrylcholinesterase (BChE) inhibitor (IC50 of 0.62 μM) and a cannabinoid receptor 2 (CB2R) agonist. hBChE-IN-2 has neuroprotection activities[1]. | [IC 50]
hBCHE: 0.67 μM (IC50); hCB2-R: 0.78 μM (IC50) | [References]
[1] Philipp Spatz, et al. Dual-Acting Small Molecules: Subtype-Selective Cannabinoid Receptor 2 Agonist/Butyrylcholinesterase Inhibitor Hybrids Show Neuroprotection in an Alzheimer's Disease Mouse Model. J Med Chem. 2023 May 11;66(9):6414-6435. DOI:10.1021/acs.jmedchem.3c00541 |
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Biorbyt Ltd.
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