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Chitin synthase inhibitor 13 (compound 12g) is a non-competitive inhibitor of chitin synthase, with an IC50 of 106.7 μM. Chitin synthase inhibitor 13 exhibits a broad-spectrum of antifungal activity[1]. | [References]
[1] Du C, et, al. Design, synthesis and biological evaluation of novel spiro-quinazolinone derivatives as chitin synthase inhibitors and antifungal agents. Eur J Med Chem. 2023 Jul 5;255:115388. DOI:10.1016/j.ejmech.2023.115388 |
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