2925364-09-4

NNRT-IN-1 (compound 8r) (1 mg/kg; i.v.) exhibits a favorable half-life of 3.66 h and a mean residence time (MRT) of 3.75 h, and the maximal concentration (C_max) is up to 431 ng/mL^[1].
NNRT-IN-1 (5 mg/kg; p.o.) exhibits a half-life of 5.18 h, a MRT of 5.21 h, a C_max value of 616 ng/mL, and the oral bioavailability (F) of 31.19%^[1].
NNRT-IN-1 (p.o.) is well tolerated at a dose of 2 g/kg^[1].