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292618-32-7

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Identification

292618-32-7 Structure

Identification	Back Directory
[Name] ST1481
[CAS] 292618-32-7
[Synonyms] ST1481 Lbq707 CPT 184 GIMATECAN Unii-7kks9R192f ST1481: GIMATECAN LBQ707; ST1481; CPT 184 7-T-Butoxyiminomethylcamptothecin 7-[(E)-tert-butyloxyiminomethyl]-camptothecin (4S)-11-((E)-((1,1-Dimethylethoxy)imino)methyl)-4-ethyl-4-hydroxy-1,12-dihydro-14H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H)-dione 1H-Pyrano(3',4':6,7)indolizino(1,2-B)quinoline-11-carboxaldehyde, 4-ethyl-3,4,12,14-tetrahydro-4-hydroxy-3,14-dioxo-, 11-(o-(1,1-dimethylethyl)oxime), (C(E),4S)-
[Molecular Formula] C25H25N3O5
[MDL Number] MFCD06795143
[MOL File] 292618-32-7.mol
[Molecular Weight] 447.49

Chemical Properties	Back Directory
[Boiling point ] 780.6±70.0 °C(Predicted)
[density ] 1.37±0.1 g/cm3(Predicted)
[storage temp. ] Store at -20°C
[form ] Solid
[pka] 11.20±0.20(Predicted)
[color ] Light yellow to yellow

Safety Data	Back Directory
[Symbol(GHS) ] GHS07,GHS08,GHS06
[Signal word ] Danger
[Hazard statements ] H300-H335-H319-H351-H315
[Precautionary statements ] P201-P202-P281-P308+P313-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501-P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362

Hazard Information

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[Uses]

Gimatecan (ST1481) is a potent topoisomerase I inhibitor. Gimatecan is an orally bioavailable camptothecin analogue with antitumor activity[1].

[Biological Activity]

Gimatecan (ST1481) is a potent topoisomerase I inhibitor. It is an orally active camptothecin analog with antineoplastic activity.

[in vivo]

Gimatecan (2 mg/kg; treatment per os, every fourth day for four times) is effective for inhibiting tumor growth.

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Animal Model:

Athymic Swiss nude mice bearing HT1376 model

Dosage:

2 mg/kg

Administration:

Treatment per os, every fourth day for four times

Result:

Caused a marked tumor growth inhibition during treatment.

[target]

Topoisomerase I

[IC 50]

Topoisomerase I

[storage]

Store at -20°C

[References]

[1] Paola Ulivi, et al. Cellular Basis of Antiproliferative and Antitumor Activity of the Novel Camptothecin Derivative, Gimatecan, in Bladder Carcinoma Models. Neoplasia. 2005 Feb;7(2):152-61. DOI:10.1593/neo.04397

Spectrum Detail	Back Directory
[Spectrum Detail] ST1481(292618-32-7)¹HNMR

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