| Hazard Information | Back Directory | [Uses]
Antibacterial agent 141 (Compound B14) has antibacterial activity against four plant pathogens Xoo, Xac, Psa and Cmm, with an EC50 value of 1.28 μM. Antibacterial agent 141 can inhibit the formation of cell membrane and change cell permeability. | [in vivo]
Antibacterial agent 141 (200 μg/mL; 7 days; single dose) is 4.64% and 43.33% of curative and protective activity toward bacterial blight, respectively[1]. | [References]
[1] Liu SS, et al. Novel spiro[chromanone-2,4'-piperidine]-4-one derivatives as potential inhibitors of fatty acid synthesis in pathogens: Design, synthesis, and biological evaluation. Eur J Med Chem. 2023 Mar 15;250:115215. DOI:10.1016/j.ejmech.2023.115215 |
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