2933183-20-9

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2933183-20-9 Structure

Identification	Back Directory
[Name] Resomelagon methanesulfonate
[CAS] 2933183-20-9
[Synonyms] Resomelagon methanesulfonate Hydrazinecarboximidamide, 2-[(2E)-3-[1-(2-nitrophenyl)-1H-pyrrol-2-yl]-2-propen-1-ylidene]-, (2E)-, compd. with methanesulfonate (1:1)
[Molecular Formula] C14H14N6O2.CH4O3S
[MOL File] 2933183-20-9.mol
[Molecular Weight] 394.41

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[Uses] Resomelagon methanesulfonate (AP1189 methanesulfonate) is the methanesulfonate salt form of Resomelagon (HY-147301). Resomelagon methanesulfonate is an orally active melanocortin receptor (MR) agonist. Resomelagon methanesulfonate induces ERK1/2 phosphorylation and Ca2+ mobilization. Resomelagon methanesulfonate exhibits anti-inflammatory activity in mouse peritonitis and peritonitis model. Resomelagon methanesulfonate can be used for obesity and chronic inflammation research[1][2].
[References] [1] Montero-Melendez T, et, al. Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol. 2015 Apr 1;194(7):3381-8. DOI:10.4049/jimmunol.1402645 [2] WHO Drug Information. International Nonproprietary Names for Pharmaceutical.

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