| Identification | Back Directory | [Name]
6-fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)benzo[b]thiophene-2-carboxylic acid | [CAS]
2936625-34-0 | [Synonyms]
PF-07328948
6-fluoro-3-(2,4,5-trifluoro-3-methoxyphenyl)benzo[b]thiophene-2-carboxylic acid |
| Hazard Information | Back Directory | [Uses]
PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats[1]. | [in vivo]
PF-07328948 (chow formulated with PF-07328948, p.o., 11 weeks) improves metabolic and heart failure end points in ZSF1 rats.[1].
| [References]
[1] Filipski KJ, et al. Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948. J Med Chem. 2024 Nov 19. DOI:10.1021/acs.jmedchem.4c02230 |
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| Company Name: |
DC Chemicals
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021-58447131 13564518121 |
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www.chemicalbook.com/showsupplierproductslist927327/0.htm |
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